Planep的用法和用量

Indications of eplerenone:

1. In congestive heart failure after acute myocardial infarction, Planep can improve the quality of life of patients with left ventricular dysfunction (ejection fraction less than or equal to 40%);

2. Planep can also be used for antihypertensive treatment. Planep can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension.

How to use Planep and dosage:

Planep dosage for adults with congestive heart failure:

Initial dose: 25 mg orally once daily; gradually increase to target dose within 4 weeks as tolerated by the patient. 

Target dose: 50 mg orally once daily.

Planep dosage for adults with high blood pressure:

Planep can be used alone or in combination with other antihypertensive drugs. 

Initial dose: 50 mg orally once daily;

Maintenance dose: 50 mg orally, 1-2 times daily;

Maximum dose: 100 mg/day;

Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.

The therapeutic advantages of Eplerenone Planep are as follows:

(1) For the treatment of heart failure after acute myocardial infarction, combined with standard treatment drugs can reduce the total mortality in the treatment group by 15% (P=0.008);

(2) Planep is equally effective as enalapril in reversing left ventricular hypertrophy and hypertension, with fewer cough side effects, and the combined effect is more obvious;

(3) There are few adverse reactions. Except for the adverse reactions of increased blood potassium, other adverse reactions are no different from the placebo group;

(4) Planep has almost no sex hormone-related side effects of spironolactone.

The above is the relevant content on the usage method and dosage. I hope it can help you!