Planep的适应症

Planep (alias: eplerenone, Inspra) is a new type of selective aldosterone receptor antagonist. It was approved for clinical use by the State Food and Drug Administration in 2002. What are the indications of Planep?

Indications of Planep:

1. Congestive heart failure after acute myocardial infarction: Planep can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that Planep can also be used for congestive heart failure after acute myocardial infarction;

2. Anti-hypertensive: Planep can be used alone or in combination with other anti-hypertensive drugs for the treatment of hypertension.

Planep has a stronger antagonizing effect on aldosterone than spironolactone, and has extremely low affinity for androgen and progesterone receptors, with few adverse reactions. It has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated. It is a good alternative to spironolactone.

For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of Planep can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction.

Advantages of using Planep:

(1) There are few adverse reactions. Except for the adverse reaction of increased blood potassium, other adverse reactions are no different from the placebo group;

(2) There are almost no sex hormone-related side effects of spironolactone.

(3) For the treatment of heart failure after acute myocardial infarction, combined use with standard treatment drugs can reduce the total mortality in the treatment group by 15% (P=0.008);

(4) Planep and enalapril are equally effective in reversing left ventricular hypertrophy and hypertension, with fewer cough side effects, and the combined effect is more obvious.