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Eplerenone was developed by Pfizer/Pharmacia under the trade name Inspra. It was first launched in the United States in 2002 and is used for the treatment of hypertension, heart failure and myocardial infarction. It has definite efficacy in treating hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated.

Eplerenone has a similar structure to aldosterone and can block the sodium-retaining potassium excretion and water retention effects of aldosterone, thereby acting as a potassium-retaining diuretic. Eplerenone is effective in reducing systolic blood pressure in patients with resistant hypertension. The European Hypertension Guidelines recommend aldosterone receptor antagonists as a treatment for resistant hypertension, and the Japanese Hypertension Guidelines also recommend them as the fourth drug in combination therapy.

Eplerenone is a safe and effective antihypertensive drug that is effective for both primary and ongoing hypertension. It is a drug of choice when fighting resistant hypertension. Moreover, eplerenone only needs to be taken once a day, simplifying the administration process. Its outstanding advantage is that for severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of this product can significantly reduce blood pressure, especially the systolic blood pressure. For patients with severe heart failure and myocardial infarction, eplerenone combined with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve quality of life and reduce mortality.

The advantages of eplerenone treatment: (1) For the treatment of heart failure after acute myocardial infarction, combined with standard treatment drugs, the total mortality rate in the treatment group can be reduced by 15%; (2) Eplerenone and enalapril are equally effective in reversing left ventricular hypertrophy and hypertension, with fewer cough side effects, and the combined effect is more obvious; (3) There are few adverse reactions, except for the adverse reactions of elevated blood potassium, other adverse reactions are no different from the placebo group; (4) There are almost no sex hormone-related side effects of spironolactone.