利伐沙班治疗静脉血栓患者效果如何？

The effect of treating patients with venous thrombosis:

Compare the clinical efficacy and safety of rivaroxaban and low molecular weight heparin sodium injection combined with low molecular weight dextran amino acid injection in the treatment of acute peripheral deep vein thrombosis of the lower limbs.

112 patients with acute peripheral deep vein thrombosis in the lower limbs were randomly divided into a control group and an experimental group, with 56 cases in each group. The control group received low molecular weight dextran amino acid injection 500 mL each time, qd, intravenous infusion + low molecular weight heparin sodium injection 0.4 mL each time, bid, subcutaneous injection; the experimental group received low molecular weight dextran amino acid injection 500 mL each time, qd, intravenous infusion + rivaroxaban 15 mg each time, bid, orally. Patients in both groups were treated for 10 days. Compare the clinical efficacy, degree of swelling and pain of the affected limb, and the occurrence of adverse drug reactions between the two groups of patients.

Results After treatment, the total effective rates of the experimental group and the control group were 92. 86% (52 cases/56 cases) and 96. 43% (54 cases/56 cases) respectively, and the difference was not statistically significant (P> 0. 05).

After treatment, the swelling degrees of the test group and the control group were (0. 87 ± 0. 45) and (0. 96 ± 0. 47) cm respectively, the pain scores were (2. 19 ± 0. 69) and (2. 35 ± 0. 62) points, respectively, and the whole blood viscosity was (9. 85 ± 2. 94) and (9. 67 ± 2. 91) m respectively. Pa · s, plasma viscosity were (1. 41 ± 0. 31) and (1. 37 ± 0. 33) m Pa · s respectively, and hematocrit were (56. 52 ± 5. 21) % and (55. 49 ± 5. 04) % respectively. The differences were not statistically significant (all P> 0. 05).

The adverse drug reactions that occurred in the test group included nausea and vomiting and gum bleeding, while those in the control group included nausea and vomiting, gum bleeding and a slight increase in transaminases. The total incidence rates of adverse drug reactions in the experimental group and the control group were 3. 57% and 5. 36% respectively, and the difference was not statistically significant (P> 0. 05).

Conclusion: The clinical efficacy and safety of combined low molecular weight dextran amino acid injection and low molecular weight heparin sodium injection combined with low molecular weight dextran amino acid injection in the treatment of acute peripheral deep vein thrombosis of the lower limbs are similar.