利伐沙班片有哪些副作用?如何减轻

(Rivaroxaban), as a new oral anticoagulant, has the advantages of easy use, little interaction with food and drugs, obvious therapeutic effect, and no need to monitor coagulation function. The drug can directly act on the key sites of the coagulation pathway and has a highly effective anticoagulant effect. It can inhibit the activity of factor xa by tightly binding to its active site and prolong the prothrombin time. At the same time, its binding to the active site of factor Xa is reversible, so the incidence of bleeding adverse events after taking the drug is low.

Despite this, patients may still experience some severe or mild side effects when actually taking this drug. In a study on the prevention of deep vein thrombosis after hip replacement in 60 cases, domestic researchers administered rivaroxaban and low molecular weight heparin respectively. The results showed that the incidence of deep vein thrombosis (DVT) in the rivaroxaban group was significantly reduced, and the incidence of bleeding events was significantly lower than that in the low molecular weight heparin group. The control of platelet and coagulation levels was equivalent to that of low molecular weight heparin.

A domestic meta-analysis of 24 included articles and 40,001 patients showed that 7 new oral anticoagulants are more effective than low-molecular-weight heparin in preventing venous thromboembolism after total hip and knee replacement, and rivaroxaban is more effective in comparing similar drugs. In addition, a meta-analysis study of 5 RCTs and 4737 patients included showed that compared with heparin/low molecular weight heparin + vitamin K antagonist, the rivaroxaban group has a significantly lower recurrence rate in deep vein thrombosis such as pulmonary embolism, and does not increase the risk of major bleeding, death, etc.

Since patients have different side effects and adverse reactions during treatment (i.e. Xarelto), if we want to reduce the symptoms and pain of patients, we need to take effective measures to deal with the symptoms based on the actual situation of the patients.

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