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(hydrocortisone) is an alternative treatment for adrenal insufficiency and congenital adrenal hyperplasia. It has shown remarkable clinical efficacy and has become an important treatment option for patients with indications. In order to ensure that patients can benefit from it, when is the best time to take hydrocortisone tablets?

Hydrocortisone tablets can be rapidly absorbed from the digestive tract. The blood concentration reaches its peak in about 1 hour. Its biological T1/2 is about 100 minutes. More than 90% of the hydrocortisone in the blood is combined with plasma proteins. Most of the metabolites are conjugated into glucuronide esters, and a very small amount is excreted unchanged in the urine. Normally, patients can take hydrocortisone tablets after meals, but patients who need to take the medication on an empty stomach and special patients need to consult a professional doctor before taking the medication.

Hydrocortisone tablets (hydrocortisone) are short-acting glucocorticoids. Because they have little negative feedback effect on the hypothalamus-pituitary-adrenocortical axis, and their action state is relatively close to the physiological state, they are generally used as replacement treatments in clinical practice. However, their anti-inflammatory effects are weak, and their mineralocorticoid activity is relatively strong, so they are mostly short-term hormone replacement treatments. They do not require hepatic conversion and can be used as replacement treatments for patients with impaired liver function.

In the treatment of adrenocortical insufficiency in adults, the recommended daily dose of hydrocortisone tablets is 20-30 mg, with 2/3 of the dose taken in the morning and the remaining 1/3 after lunch. During the medication period, if the patient is under stress, the dosage should be increased appropriately. Specifically, the dose can be increased to 80 mg per day and taken in divided doses. For children, the dosage of the drug is 20-25/m² based on body surface area per day, divided into 3 times, once every hour.

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