氢化可的松片对肾上腺皮质增生的效果

(hydrocortisone) is a drug used to treat adrenal hyperplasia, and it has shown good therapeutic effects. Domestic patients can purchase and use it with confidence.

To explore the early diagnosis and oxidation of corticosteroids in congenital adrenal hyperplasia (CAH) Regarding the therapeutic effect of pine, a domestic study retrospectively analyzed 14 inpatients diagnosed with CAH from February 2006 to August 2010, summarized their main clinical manifestations, laboratory test results and imaging characteristics, compared the patients' height, weight, head circumference and other growth and development indicators, explored their cortisol secretion rhythm and the correlation between cortisol levels and serum electrolytes, and evaluated the therapeutic effect of hydrocortisone on electrolyte disorders in patients with CAH. Statistical analysis was performed using SPSS13.0 software.

The results showed that the main clinical manifestations of 14 CAH patients were dehydration, food refusal, vomiting, diarrhea, malnutrition and weight loss, 12 cases had abnormal development of external genitalia, and 10 cases were accompanied by pigmentation. The patient gradually developed stunted growth in the first year of life, and the increase in weight and head circumference significantly lagged behind the height. In patients with 21-hydroxylase deficiency salt-wasting type, a common subtype of CAH, serum cortisol levels at 16:00 were negatively correlated with serum sodium ion levels (r=-0.83, p<0.05, the comparison between groups was statistically significant), and positively correlated with serum calcium ion levels (r=0.93, P<0.05, the comparison between groups was statistically significant). Intravenous infusion of hydrocortisone can improve hyponatremia (t=2.98, P<0.05, the comparison between groups is statistically significant), hyperkalemia (t=6.23, P<0.01, the comparison between groups is statistically significant) and hypochloremia in patients with salt-wasting type (t=2.60, P<0.05, the comparison between groups is statistically significant).

In summary, it is an effective drug for the treatment of CAH.

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