甲磺酸贝舒地尔片可以治疗闭塞性支气管炎吗？

Author: Medicalhalo

Release time: 2025-10-19 11:44:20

It is a drug used to treat chronic graft-versus-host disease (cGVHD). Studies have shown that Besudil mesylate tablets can also treat bronchitis obliterans, which can relieve cough, wheezing, dyspnea and other uncomfortable symptoms to a certain extent, and improve the patient's quality of life.

Efficacy of Besudil mesylate tablets in the treatment of bronchitis obliterans

Chronic graft-versus-host disease (cGVHD) or bronchiolitis obliterans syndrome (BOS) in the lungs is a high-risk disease manifestation associated with poor prognosis. Currently available treatments have limited clinical efficacy in this setting.

Besudil mesylate tablets are a new oral and selective rho-associated coiled-coil protein kinase-2 inhibitor that was recently approved by the US Food and Drug Administration for the treatment of cGVHD.

Fifty-nine subjects with BOS were identified who were enrolled and treated in 2 prospective clinical trials of besudil mesylate tablets.

Among registry and clinician-attributed lung diseases to cGVHD, patients with BOS had a predicted percent forced expiratory volume in 1 second (Fev1) ≤79%. At the time of enrollment, the National Institutes of Health (NIH) cGVHD lung score was 1, 2, or 3. The best overall response rate (ORR) for pulmonary cGVHD according to NIH response criteria was 32% (partial response: 17%; complete response rate: 15%).

The response rate is inversely proportional to the baseline NIH GVHD lung score at enrollment (lung score 1: ORR 50%; lung score 2: response rate 17%, lung score 3: response rate 0%). In multivariable analysis, male sex, lower baseline NIH cGVHD lung score, and partial response to preenrollment cGVHD therapy were associated with higher lung-specific response rates. There were no significant correlations between lung function assessments and patient symptom measures.

In conclusion, treatment with besudil mesylate tablets was associated with lung-specific clinical responses in subjects with bronchiolitis obliterans syndrome, which was more common in advanced disease. Optimization of treatment response assessment in patients with bronchiolitis obliterans syndrome remains a challenge.

Besudil mesylate tablets for the treatment of chronic graft-versus-host disease

Chronic graft-versus-host disease is a complication of allogeneic hematopoietic cell transplantation (HCT) and the main cause of late non-relapse mortality (NRM). There are currently three new drugs approved for the treatment of cGVHD. Among them, besudil mesylate tablets have a unique dual mechanism of action that targets Rho-GTPase-related coiled-coil kinase 2 in T helper follicular cells (TFH) and TH17 cells, which leads to the downregulation of pro-inflammatory cytokines. The former inhibits tissue fibrosis by inhibiting the Rho-ROCK-MRTF pathway by inhibiting the Rho-ROCK-MRTF pathway by targeting stress-induced G-actin fibril polymerization.

Besudil mesylate tablets are approved for the treatment of adults and children over 12 years old with cGVHD who have failed two lines of therapy, based on the results of the ROCKstar study, which showed a high overall response rate (ORR), a favorable adverse reaction profile and a low rate of serious infections.

Usage and Dosage of Besudil Mesylate Tablets

The recommended dosage of Besudil Mesylate Tablets is 200 mg, taken orally once a day with a meal.

Precautions for bronchitis obliterans

1. Pay attention to hygiene: ventilate the room regularly, keep the air fresh, avoid smoke irritation and stay away from allergens.

2. Avoid going to crowded places: During the respiratory disease epidemic season, try to avoid going to crowded places and avoid contact with patients with respiratory infections.

3. Pay attention to hygiene: Hands are the media that spread many diseases. Pay attention to personal hygiene and hand hygiene, and wash your hands frequently.

4. Appropriate exercise: You should participate in more outdoor activities, such as climbing stairs or walking, to enhance your resistance. Try to choose a park that is open, has water, trees, and few people as the training environment. The fresh air is good for breathing.

5. Maintain good living habits: Maintain a good routine and good sleep quality, which helps growth and development and improves the body's resistance.

Summary

Besudil mesylate tablets can be used to treat bronchitis obliterans, but during the treatment process, patients should strictly follow the doctor's instructions and do not adjust the dosage without permission to avoid side effects such as cough, abdominal pain, diarrhea, edema, bleeding, dyspnea, infection, etc. At the same time, regular follow-up observations should be carried out, lung HRCT and lung function should be reexamined at selected intervals, and assessments should be conducted every 3-6 months, and the treatment plan should be adjusted according to changes in the condition and treatment effects.