甲磺酸贝舒地尔片导致的不良反应怎么治疗？

Introduction: Besudil mesylate tablets are inhibitors of rho-associated coiled-coil protein kinase (ROCK), which help to resolve immune disorders by changing the balance between Th17 cells and T regulatory cells, thereby inhibiting the sometimes fatal inflammatory cascade, and can be used to treat chronic graft-versus-host disease (GVHD).

What are the adverse reactions caused by Besudil Mesylate Tablets

1. Infection: including various types of infections, such as viral infections, bacterial infections, etc.

2. Fatigue: Feeling tired or weak.

3. Nausea: May cause stomach discomfort or vomiting.

4. Diarrhea: May cause frequent, watery stools.

5. Edema: It may cause swelling in certain parts of the body.

6. Bleeding: including various types of bleeding, such as epistaxis, gastrointestinal bleeding, etc.

7. Abdominal pain: You may feel abdominal pain or discomfort.

8. Other adverse reactions: such as skeletal muscle pain, headache, increased gamma-glutamyl transferase, decreased lymphocyte count, hypertension, cough, loss of appetite, rash, itching, etc.

You should seek medical treatment promptly after occurrence and follow the doctor's instructions for treatment. The doctor may recommend adjusting the dosage of the drug or taking other treatment measures to control side effects.

Measures for dealing with adverse reactions of Besudil Mesylate Tablets

1. Infection: If symptoms of infection occur, such as fever, chills, etc., you should seek medical treatment in time. The doctor may prescribe antibiotic treatment and may need to suspend the use of Besudil Tablets until the infection is controlled.

2. Fatigue: Fatigue may affect daily activities. It is recommended to maintain adequate rest, adjust the dosage or consider other treatment measures under the guidance of a doctor.

3. Nausea and diarrhea: For nausea and diarrhea, you can try to adjust your diet, avoid irritating foods, and use antiemetics and antidiarrheals. In severe cases, temporary discontinuation of the medication may be necessary.

4. Edema: Edema may be caused by fluid retention, which may require the use of diuretics and limiting salt intake.

5. Bleeding: Timely medical treatment is required, and the dose may need to be adjusted or the treatment plan changed.

Doctors will provide targeted treatment based on the specific side effects.

Dosage and Administration of Besudil Mesylate Tablets

The recommended dose of Besudil Mesylate Tablets is 200 mg, taken once daily until progression of chronic GVHD requiring new systemic therapy. Patients should swallow besudil mesylate tablets whole and do not cut, crush or chew the tablets.

It should be noted that if a dose of Besudil Mesylate Tablets is missed, the patient does not need to take additional doses to make up for the missed dose.