他克莫司胶囊(Prograf)正品在哪里购买

Tacrolimus capsules (Prograf) are mainly used to prevent organ rejection after kidney transplantation or liver transplantation. Both the original drug and the generic drug are covered by medical insurance, and patients need to purchase it with a prescription.

Where to buy authentic tacrolimus capsules (Prograf)

Tacrolimus capsules have been launched in China. The original drug specification is 0.5mg*100 tablets and the price is about US$110. The following are reliable ways to purchase authentic products:

Offline pharmacies

Patients can go to the pharmacy of a hospital with an organ transplantation department to purchase the drug. After the doctor issues a prescription based on the postoperative situation, the patient purchases it with the prescription. Some large chain pharmacies also offer this medicine, and you need to call to confirm the inventory and storage conditions before purchasing. When purchasing medicines, you need to check the integrity of the packaging, check the production batch number and expiration date, and avoid purchasing products that are close to expiration.

Online platform

If patients find it troublesome to go to the hospital to buy, they can also buy directly online and check the drug anti-counterfeiting labels after purchasing.

No matter which channel you choose, please keep the drug purchase invoice and outer packaging to facilitate subsequent quality traceability or medical insurance reimbursement.

How should you store tacrolimus capsules (Prograf) after purchasing them?

Tacrolimus is sensitive to storage conditions. Improper storage may lead to reduced efficacy or deterioration. The following are specific storage requirements:

Storage methods for unopened medicines

Original packaged medicines must be stored in a cool, dry place with an ambient temperature not exceeding 25°C, away from direct sunlight or moisture. Do not freeze in the refrigerator, as low temperatures may cause the capsule shell to rupture. If the aluminum sealing film of the medicine bottle is damaged or the capsule appears discolored or agglomerated, use should be stopped immediately.

Management of opened medicine bottles

After opening, the bottle cap must be tightened and stored in the original packaging box. Record the date of opening after each medicine is taken. It is usually recommended to use it within 3 months. If the desiccant in the bottle is found to change color, such as from blue to pink, it means that the ambient humidity is too high and the storage location needs to be changed.

Suggestions for carrying when traveling or going out

When going out for a short period of time, you can use a portable medicine box to pack 1-2 days' worth to avoid carrying the entire bottle of medicine. For long-term travel, you need to prepare an insulated thermal bag with a built-in ice pack to maintain the temperature between 15-25°C. When flying, it is recommended to carry copies of medicines and prescriptions with you to avoid temperature control caused by checked luggage.

Check the storage environment temperature once a month, which can be monitored with a household thermometer. If the living environment is high for a long time, you can purchase a special medicine refrigeration box (non-freezing layer) for storage.

Usage and dosage of Tacrolimus Capsules (Prograf)

Tacrolimus needs to be taken strictly according to the individualized plan. Dosage deviations may lead to rejection or toxicity risks.

Correct time and method of taking the medicine

Take it on an empty stomach at a fixed time every day. Take the whole capsule with warm water 1 hour before or 2 hours after a meal. If the missed dose does not exceed 14 hours, you can take it immediately; if it exceeds 14 hours, skip this dose and take the medicine normally the next day. Do not crush, chew or dissolve capsules as this may damage the sustained-release structure.

Dose adjustment and blood drug concentration monitoring

The initial dose for adults is 0.15-0.20mg/kg per day, adjusted according to the blood drug concentration. The target concentration is 7-15ng/mL in the first month after surgery, and then gradually reduced to 5-10ng/mL. After each dose adjustment, the plasma concentration needs to be rechecked within 3 days.

Interactions between diet and drugs

Do not consume grapefruit, pomegranate and alcohol while taking the drug. These substances will interfere with drug metabolism. Aluminum/magnesium-containing stomach medicine needs to be taken 2 hours apart.

In daily care, patients need to monitor body temperature, blood pressure and urine output every day, record abnormal symptoms, maintain a balanced diet, limit high-salt and high-fat foods, and perform light aerobic exercise three times a week.