磷酸二甲酯片(Astomin)的功效与作用

Dimethyl phosphate tablets (Astomin) were developed by OrphanPacific of Japan and were first approved for marketing in Japan in 1975.

Efficacy and effects of dimethyl phosphate tablets (Astomin)

1. Antitussive effect

Mainly by acting on the medulla oblongata cough center, reducing its sensitivity to stimulation, thereby inhibiting the cough reflex.

2. Narcotic properties

Long-term animal experiments have not found physical or mental dependence. It is a non-narcotic antitussive and is highly safe to use.

3. Little impact on intestinal function

Unlike codeine, dimethyl phosphate does not significantly inhibit intestinal peristalsis while antitussive and is not likely to cause constipation.

Indications and applicable groups of Dimethyl Phosphate Tablets (Astomin)

1. Indications

Applicable to coughs caused by the following diseases:

(1), upper airway inflammation, pneumonia, and acute bronchitis.

(2) Chronic respiratory diseases: chronic bronchitis, tuberculosis, lung cancer, pneumoconiosis and pneumoconiosis tuberculosis, etc.

2. Adaptable crowd

(1) Adults (15 years old and above): are the main users.

(2) Elderly people: Due to the decline in physiological functions, the dosage needs to be reduced as appropriate.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Usage and dosage of dimethyl phosphate tablets (Astomin)

1. Standard dose

Adults take 1-2 tablets (equivalent to 10-20 mg of dimethyl phosphate) orally each time, 3 times a day.

2. Adjustment suggestions

The dose can be appropriately adjusted according to the patient's age, severity of disease, etc. For the elderly, a low initial dose should be started.

3. Precautions for taking

(1). The tablets need to be taken out from the PTP aluminum foil to avoid accidental swallowing of the packaging, which may cause esophageal damage.

(2). Taking it after meals can reduce gastrointestinal discomfort.

Side effects of dimethyl phosphate tablets (Astomin)

Common side effects

1. Psychiatric nervous system: dizziness, drowsiness, headache.

2. Digestive system: dry mouth, loss of appetite, nausea, diarrhea.

3. Occasionally, skin rash, palpitations, facial flushing and other allergic reactions may occur.

Pharmacokinetics of dimethyl phosphate tablets (Astomin)

1. Absorption

Plasma concentration reaches peak about 1-2 hours after oral administration of dimethyl phosphate tablets, and its peak concentration is 0.007-0.008 μg/mL.

2. Metabolism

The metabolites are mainly oxidative dealkylation products and have almost no antitussive activity.

3. Excretion

After oral administration of 30 mg to healthy adult men, the urinary excretion rate within 24 hours is approximately 60%, of which less than 2% is the original drug.