慢性阻塞性肺病用药罗氟司特效果怎么样？有副作用吗？

Roflumilast, a drug approved for chronic obstructive pulmonary disease (COPD), is a new, highly selective phosphodiesterase 4 inhibitor. It is not used to treat other types of COPD such as primary emphysema, but it has broad application prospects in the treatment of bronchial asthma in the future.

So, how effective is roflumilast?

More than 3,000 COPD patients were included in two pivotal placebo-controlled clinical studies. Studies have proven that this product can significantly improve patients with moderate to severe exacerbations and prediastolic FEV1, regardless of whether it is combined with a long-acting β2 agonist. The results of a 24-week randomized controlled trial showed that ACQ improvement reached minimal clinical significance in the 500 μg group when treated with placebo, 250 μg roflumilast, and 500 μg roflumilast. The results of another 24-week randomized controlled study showed that there was a statistically significant difference in the improvement of ACQ between high-dose roflumilast (500 μg) combined with 400 μg beclomethasone propionate and placebo combined with 400 μg beclomethasone propionate.

Does Roflumilast have any side effects?

Although roflumilast has a good therapeutic effect, it also has side effects. Diarrhea, weight loss, nausea, headache, back pain, influenza, insomnia, dizziness and loss of appetite are relatively common side effects of roflumilast. The overall safety is tolerable. Patients need to receive symptomatic treatment under the guidance of a doctor and take medication on time and in the right amount. Do not change the dosage and usage of the medication at will to avoid intolerance reactions.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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