罗氟司特的用法用量和注意事项是什么？

Roflumilast is used for chronic obstructive pulmonary disease (COPD) and was approved for marketing by the European Union in July 2010 and by the U.S. Food and Drug Administration (FDA) on March 1, 2011. It is an inhibitor called phosphodiesterase-4 (PDE-4) and is a new drug for the treatment of COPD.

So, what is the dosage of roflumilast?

The recommended dose of roflumilast is one tablet a day. The tablets should be swallowed with water at the same time every day. They can be taken with or without food. The maintenance dose is one tablet a day at a dose of 500 micrograms (mcg). At the beginning of treatment, the dose is 250 mcg once a day for 4 weeks, and then increased to 500 mcg once a day, which can reduce the treatment interruption rate in some patients. Patients may need to take roflumilast for several weeks before it starts to take effect. In case of overdose, patients should seek medical attention immediately.

So, what are the precautions for roflumilast?

It is recommended that roflumilast not be used with strong cytochrome P450 enzyme inducers; if unexplained or clinically significant weight loss occurs, evaluate weight loss and consider discontinuing use; do not use to relieve acute bronchospasm; carefully weigh the risks and benefits of treatment with roflumilast in patients with a history of depression and/or suicidal thoughts or behaviors; roflumilast is contraindicated in patients with moderate to severe hepatic impairment. For more details about the use of roflumilast, it is recommended to read the drug package insert. At present, the drug is not on the market in the country. Patients in need can contact Medical Companion Travel for more details.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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