莱博雷生的用法用量

Dayvigo is a new orexin receptor antagonist used to treat insomnia in adults, especially for difficulty falling asleep and maintaining sleep. This article will introduce the key points of clinical application of this drug in detail from three aspects: standard usage and dosage, common side effects, and medication precautions for special groups, to help patients and medical staff use this treatment option correctly.

Usage and Dosage of Leborexan

Patients should use it correctly under the guidance of a doctor. The following describes the specific usage method from three aspects: standard dosage regimen, dosage adjustment principle and medication time requirements.

Standard dosage regimen

The recommended starting dose is 5mg, taken once every night before going to bed. Based on clinical response and tolerability, the dose may be gradually increased to the maximum recommended dose of 10 mg. The daily dose should not exceed 10 mg, and the interval between two doses should be at least 24 hours.

Principles for dose adjustment

When used in combination with weak CYP3A inhibitors, the maximum dose is limited to 5 mg. Patients with moderate hepatic impairment should also be limited to 5 mg. Not recommended for patients with severe hepatic impairment. The elderly (≥65 years old) should carefully assess the risks when using doses higher than 5 mg.

Medicine administration time requirements

It should be taken at least 7 hours before the planned wake-up time. Avoid taking it with high-fat meals, otherwise the onset of effect may be delayed by 1-2 hours. If you miss a dose, skip the dose and continue taking the medication as originally planned the next day.

Following these medication guidelines can maximize the effectiveness of treatment while reducing the risk of adverse reactions.

Side Effects of Leborexen

Understanding the potential adverse effects of Leborexen can help with early identification and management. The following is an explanation from three aspects: common reactions, neurological effects and special adverse reactions.

Common adverse reactions

Daytime drowsiness is the most reported side effect. Some patients may experience minor discomforts such as headache and fatigue, which usually diminish as the medication is prolonged.

Nervous system effects

Patients may experience sleep paralysis or sleep/wake hallucinations. A few patients may have complex sleep behaviors, such as walking or eating during sleep. These symptoms mostly occur in the early stages of treatment.

Special Adverse Reactions

There are reports that it may induce cataplexy-like symptoms, especially in patients prone to narcolepsy. Patients with impaired respiratory function may experience worsening respiratory depression and require close monitoring.

Recognizing these side effects can help to take timely intervention measures.

Special population use of leborexan

Special attention should be paid to dose adjustment and monitoring when used by different groups of people. The following explains the precautions from three aspects: those with abnormal liver and kidney function, elderly patients, and pregnant and lactating women.

Patients with abnormal liver and kidney function

The maximum dose for patients with moderate liver damage is limited to 5 mg, and it is contraindicated for patients with severe liver damage. Dosage adjustments are generally not required in patients with renal impairment, but severe renal impairment may increase the risk of drowsiness and requires close monitoring.

Geriatric patients

Patients over 65 years old have an increased risk of falls when using doses higher than 5 mg. The recommended starting dose is 5 mg, with slow titration and assessment of balance function and fall risk.

Pregnant and lactating women

Safety data during pregnancy are limited, and the pros and cons should be weighed. The safety of use during lactation has not been established, and it is recommended to suspend breastfeeding. Women of childbearing age should take reliable contraceptive measures during medication.

Developing individualized medication plans based on the characteristics of different groups of people can improve the safety of treatment.