打完唑来膦酸注意事项有哪些？

Zoledronic Acid belongs to the bisphosphonate class of drugs. Its main function is to inhibit the destruction of bone cells. It is also used for bone metastasis cancer and has a bone-protecting effect. On the one hand, its effect can protect bone cells and have a certain analgesic effect. Of course, zoledronic acid needs to be applied regularly, usually at intervals of four weeks, that is, once a month. It is more effective in treating bone metastases. For bone metastasis, in addition to drug treatment, if the pain is severe, local radiotherapy can also be used, which also has an analgesic effect.

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1. When using this product for the first time, the levels of calcium, phosphorus, magnesium and serum creatinine in the serum should be closely monitored. If the levels of calcium, phosphorus and magnesium in the serum are too low, necessary supplementary treatment should be given;

2. Patients with malignant hypercalcemia should fully rehydrate before taking this product. Diuretics can only be used after sufficient rehydration when combined with this product. Caution should be used when this product is combined with nephrotoxic drugs;

3. If renal function worsens when receiving this product, the drug should be discontinued until renal function returns to baseline;

4. Asthma patients who are allergic to aspirin should use this product with caution.

5. It is not clear whether this product will be secreted into breast milk. Because this product can combine with bones for a long time, pregnant and lactating women are prohibited from using this product.

6. The safety and effectiveness of this product in children have not been established, and its use is not recommended for the time being.

7. Medication for the elderly should be the same as for adults. However, elderly patients often have lower renal function and their renal function should be closely monitored during administration.

8. Drug interactions: Caution should be exercised when using this product in combination with aminoglycosides, because aminoglycosides have a synergistic effect in lowering blood calcium and may prolong the duration of hypocalcemia; when used in combination with diuretics, the risk of hypocalcemia may be increased, and when used in combination with thalidomide, the risk of abnormal renal function in patients with multiple myeloma may be increased. It's not clear yet.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.