唑来膦酸副作用是什么,治疗骨转移需使用多久？

Zoledronic acid increases bone density and enhances bone strength by inhibiting osteoclasts and bone cell resorption. Zoledronic acid can be used to treat pain caused by osteolytic bone metastasis of malignant tumors. It has a certain effect in the treatment of osteoporosis and bone hyperplasia, especially in the treatment of senile and menopausal osteoporosis. So, what are the side effects of zoledronic acid, and how long does it take to treat bone metastases?

What are the side effects of zoledronic acid?

Renal function, serum calcium, and electrocardiogram need to be checked when using zoledronic acid. Common side effects include fatigue, chest pain, leg edema, vomiting, constipation, diarrhea, abdominal pain, dysphagia, anemia, hypokalemia, hypomagnesemia, anorexia, hypotension, bone pain, conjunctivitis, nausea, joint pain, myalgia, dyspnea, cough, pleural effusion, etc., and fever is.

In addition, urinary tract infection, upper respiratory tract infection, anorexia, weight loss, dehydration, flu-like symptoms, redness and swelling at the injection site, rash, itching, increased serum creatinine value (related to the time of administration), etc. are also manifestations of the side effects of zoledronic acid. During the period of medication, patients should pay attention to replenishing water, taking in more calcium-rich foods, and spending more time in the sun. Calcium and vitamin D need to be supplemented when necessary.

How long should zoledronic acid be used to treat bone metastasis?

Since bone metastasis causes bone destruction, zoledronic acid helps control bone metastasis. Zoledronic acid is used to treat bone metastasis once a year for 3 years. If zoledronic acid is used to treat complications associated with malignant bone tumors, it may need to be used every 3 to 4 weeks, depending on the condition. After injecting zoledronic acid, the osteoclastic process, or bone destruction, in the body is greatly reduced. Supplementing exogenous calcium at this time can promote bone reconstruction and play an anti-osteoporosis role. The above is the side effects of zoledronic acid and how long it needs to be used to treat bone metastases.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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