地诺单抗哪里有卖？

Where to buy it? At present, denosumab has not yet been launched in China. What is available in other regions such as the United States and Türkiye is denosumab, the original manufacturer of American Amgen. The Turkish version of denosumab is currently the most cost-effective. For more information, please consult the Medical Companion Travel Service.

Denosumab is a bone resorption inhibitor with a unique mechanism of action. It specifically targets the receptor activator of NF-kB ligand (RANKL), inhibits the activation and development of osteoclasts, reduces bone resorption, and increases bone density. On May 28, 2010, the European Commission approved this product for the treatment of bone loss related to hormone suppression in postmenopausal women with osteoporosis and prostate cancer patients. It can also be used in patients for whom other current treatments are ineffective or intolerable to reduce the risk of fractures.

Denosumab and bisphosphonates are two drugs that must be mentioned in the treatment of cancer bone metastasis. Like bisphosphonates, denosumab can reduce complications related to bone metastasis and prevent fractures; unlike bisphosphonates, denosumab targets a different protein receptor. Denosumab and bisphosphonates have different mechanisms of action. Denosumab appears to be more effective than zoledronic acid (Zometa) in preventing fractures in patients who have already developed bone metastases. It can help improve bone quality even after bisphosphonates have failed.

It has better therapeutic advantages for patients with bone metastases. In addition, it should be noted that the drug is a subcutaneous injection, which is simple to operate and affordable. During use, you need to pay attention to supplementing vitamin D and calcium. In terms of adverse reactions, common adverse reactions with denosumab include: fatigue/weakness, low phosphate levels in the blood, and nausea. Adverse effects of denosumab in patients with giant cell tumor of bone include: arthralgia, headache, nausea, pain, fatigue, and pain in the extremities.