地舒单抗用法和用量

Xgeva is a drug used to treat bone metastases and prevent bone-related events in patients with solid tumors. To achieve its best effect, you must read the instructions carefully and understand its usage and dosage.

Desosumab is available in 120 mg/1.7 mL (70 mg/mL) single-use vials. Refrigerate at 2-8°C (36-46°F); do not freeze. Must be used within 14 days after removal from the refrigerator, do not expose to temperatures above 25°C (77°F), and avoid direct light and heat. Give 120 mg by subcutaneous injection into the upper arm, upper thigh, or abdomen once every 4 weeks.

Hypocalcemia must be corrected before starting treatment with denosumab Xgeva. For patients who are prone to hypocalcemia and mineral metabolism imbalance (such as those with a history of hypoparathyroidism, thyroid surgery, parathyroid surgery, malnutrition, small bowel resection, severe renal insufficiency), clinical monitoring of creatinine and mineral levels is required, and such patients should be instructed to pay attention to the symptoms of hypocalcemia and to supplement adequate amounts of calcium and vitamin D.

Patients who are concurrently taking immunosuppressants or have compromised immune systems may be at increased risk of serious infections, and physicians need to fully consider the benefit-risk ratio before prescribing denosumab to such patients.

Allergic reactions may occur with the use of denosumab Xgeva; if an allergic reaction occurs, the drug should be permanently discontinued. Denosumab may harm the fetus. Women of childbearing age should be informed of the dangers of the drug and take effective contraceptive measures. Its safety and effectiveness have not been established in pediatric patients and use in pediatric patients is not recommended. In order to avoid other adverse injuries during medication, patients should promptly and truthfully inform their doctors if they have other special circumstances, including the need to take other medications.

The above is an introduction to the use of Xgeva. Since each patient's own situation is different, please consult a doctor with relevant treatment experience before treatment, and strictly follow the doctor's instructions during treatment.