Xgeva治疗骨转移效果好吗？

It is a human IgG2 monoclonal antibody obtained through genetic engineering. It is a bone resorption inhibitor with a unique mechanism of action. It specifically targets nuclear factor κB receptor activator ligand (RANK), inhibits the activation and development of osteoclasts, reduces bone resorption, and increases bone density. It has specific affinity for human RANKL and is a drug that specifically targets RANK ligand. Xgeva binds to RANKL on the surface of osteoclasts and their precursor cells, blocking the binding of RANKL to RANK receptors, preventing the generation, survival and function of osteoclasts, reducing bone resorption and increasing the bone mass and strength of cortical and cancellous bones. Is Xgeva effective in treating bone metastases?

Data from a study on Xgeva: Compared with zoledronic acid, denosumab is more effective in preventing complications of bone metastases from solid tumors or multiple myeloma. Compared with zoledronic acid, Xgeva can significantly delay the onset of SREs in patients with breast cancer bone metastases, reduce the risk of multiple SREs by 23%, significantly delay the onset of pain by 3.9 months, and reduce the use of powerful opioid analgesics. In addition, the subcutaneous injection of Xgeva (desosumab) has greatly improved patients' medication compliance.

At present, a number of domestic and foreign authoritative guidelines have unanimously affirmed the status of Xgeva in breast cancer bone metastasis, and recommended that Xgeva (desosumab) should be started after the diagnosis of breast cancer bone metastasis.

Hypocalcemia must be corrected before starting treatment. For patients who are prone to hypocalcemia and mineral metabolism imbalance (such as those with a history of hypoparathyroidism, thyroid surgery, parathyroid surgery, malnutrition, small bowel resection, severe renal insufficiency), clinical monitoring of creatinine and mineral levels (such as phosphorus and magnesium) is required, and such patients should be instructed to pay attention to the symptoms of hypocalcemia and to supplement adequate amounts of calcium and vitamin D.