Denosumab去哪里买的到？

It is a RANK ligand (RANKL) inhibitor produced by Amgen. Where can I buy Denosumab?

It was approved on November 18, 2010, to prevent bone-related events caused by cancer that has spread to the bone, and on June 13, 2013, for the treatment of adults and adolescents with giant cell tumor of bone (GCTB), a rare and usually noncancerous tumor. In May 2019, Denosumab was conditionally approved for marketing in China, and patients can purchase Denosumab with a prescription. However, the price of Denosumab in China is relatively high, so many patients buy Denosumab, which is available in Turkey, and the price is about $3,000 for 120 mg. For specific prices and drug purchase information, please consult Medical Companion Travel.

Denosumab is the first approved monoclonal antibody specifically targeting RANK ligand. RANK ligand is a transmembrane or soluble protein that is necessary for osteoclasts to maintain their structure, function, and survival. Human RANKL mRNA is mainly found in bones, bone marrow and lymphoid tissues. Its main function in bones is to stimulate the differentiation and activity of osteoclasts and inhibit the apoptosis of osteoclasts. Osteoclasts are responsible for bone resorption, and osteoclast precursors must have low levels of macrophage colony-stimulating factor and RANKL during their differentiation into mature osteoclasts.

Usage and dosage: Solid tumor bone metastasis: 120mg once every 4 weeks, injected subcutaneously in the upper arm, thigh or abdomen. Giant cell tumor of bone: 120 mg subcutaneously every 4 weeks, followed by 120 mg on days 8 and 15 during the first month of treatment. Malignant hypercalcemia: 20 mg subcutaneously every 4 weeks, followed by 120 mg on days 8 and 15 during the first month of treatment. The medication is injected under the skin in the upper arm, thigh, or abdomen.