狄诺塞麦上市了吗？价格多少？

The trade name is Xgeva, which is a bone resorption inhibitor with a unique mechanism of action. This is a new targeted drug developed by the American company Amgen. Its target is receptor activator of nuclear factor kappa B ligand (RANK), thereby inhibiting the activation and development of osteoclasts, reducing bone resorption and increasing bone density.

Denosumab can prevent RANK ligand from activating RANK on the surface of osteoclasts, promote bone reconstruction, and reduce the incidence of vertebral, non-vertebral and hip fractures in postmenopausal osteoporotic women. It has demonstrated positive therapeutic effects in multiple clinical trials and improved patients' quality of life.

Many patients may ask after seeing this, is denosumab on the market? How much does it cost?

Denosumab was first approved for marketing in the EU in May 2010 and was approved by the FDA in June for the treatment of bone loss related to hormone suppression in postmenopausal women with osteoporosis and prostate cancer. In the same year, it was approved for marketing in Norway, Iceland, Liechtenstein and other countries or regions. It is understood that the price of the original drug produced by Amgen Company of Denosumab in the United States is approximately US$1,169.98, and the specification is 60mg/1ml tube/box.

In 2018, denosumab entered my country's fast-track approval channel and is also one of the drugs on my country's clinically urgently needed overseas new drug list (first batch). In May 2019, denosumab lived up to expectations and passed national approval and was officially launched in China for the treatment of adults and skeletally mature adolescent patients whose giant cell tumor of bone is unresectable or whose surgical resection may cause severe functional impairment. It is understood that the domestic price of the original denosumab drug is approximately RMB 5,298, and the specification is 120mg/1.7ml bottle/box.

Both the United States and China have very high pricing. In addition, Denosumab produced by Amgen has also been launched in Turkey. The price is relatively low, with 120mg priced at about $3,000. It is a good choice for domestic patients.