地舒单抗适用于治疗什么病症呢？

On November 18, 2010, denosumab was approved to prevent bone-related events caused by cancer that has spread to the bones. On June 13, 2013, denosumab was approved to treat adults and adolescents with giant cell tumor of bone (GCTB), a rare and usually noncancerous tumor.

Desosumab (denosumab) is a RANK ligand (RANKL) inhibitor with a different mechanism of action than currently approved drugs that reduce skeletal complications of tumors. It is a fully humanized monoclonal antibody (IgG2 monoclonal antibody) that specifically targets receptor activator of nuclear factor-κB ligand (RANKL). It prevents RANKL from binding to its receptor substances, inhibits osteoclast activation and development, reduces bone resorption, and increases bone density.

Desosumab is an injection that requires subcutaneous injection of 120 mg into the upper arm, upper thigh, or abdomen once every 4 weeks. Calcium and vitamin D are given when treatment or prevention of hypocalcemia is required. The most common adverse reactions (incidence greater than or equal to 25% per patient) in patients receiving denosumab were fatigue/asthenia, hypophosphatemia, and nausea.

Hypocalcemia must be corrected before denosumab (denosumab) therapy can be initiated. For patients who are prone to hypocalcemia and mineral metabolism imbalance (such as those with a history of hypoparathyroidism, thyroid surgery, parathyroid surgery, malnutrition, small bowel resection, severe renal insufficiency), clinical monitoring of creatinine and mineral levels is required, and such patients should be instructed to pay attention to the symptoms of hypocalcemia and to supplement adequate amounts of calcium and vitamin D.

Patients who are concurrently taking immunosuppressants or have compromised immune systems may be at increased risk of serious infections, and physicians need to fully consider the benefit-risk ratio before prescribing denosumab to such patients. For patients who develop serious infections while taking denosumab, physicians should evaluate the need for continued use.

The above are the applicable diseases, I hope it will be helpful to you.