狄诺塞麦打完多久见效？

In China, clinical treatment methods for bone metastases are limited. Currently, the main treatment method is regular monthly intravenous administration of bisphosphonate drugs (disodium pamidronate, zoledronic acid). In severe cases, radiotherapy and other treatments can be used. However, in countries and regions such as Europe, the United States, and Hong Kong, it is the first choice for the treatment of bone metastases.

A 3-year randomized, double-blind, placebo-controlled phase III clinical trial FREEDOM (Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months) evaluated the efficacy and safety of denosumab in the treatment of osteoporosis in postmenopausal women. Patients were randomly assigned to: treatment group (60 mg subcutaneous injection of this product every 6 months, n = 3902) or placebo (n = 3906).

The primary evaluation indicator was the incidence of new vertebral fractures during the 3-year period, and secondary indicators included the incidence of hip fractures and non-vertebral fractures and the time to first fracture during the observation period. The subjects were aged between 60 and 90 years old, with an average age of 72.3. The basic value of spine or total hip T-score was between -4.0 and -2.5 (the average was -2.8). About 23% of the subjects had a history of at least one fracture before entering this trial. All patients also received daily supplements of 1,000 mg of vegetarian calcium and 400 to 800 IU of vitamin D. The results showed that compared with the placebo group, the incidence of new vertebral fractures in the treatment group was reduced by 68% (the treatment group was 2.3%, the placebo group was 7.2%, P < 0.000 1), the incidence of hip fractures was relatively reduced by 40% (the treatment group was 0.7%, the placebo group was 1.2%, P = 0.036), and the incidence of non-vertebral fractures was relatively reduced by 20% (the treatment group was 6.5%) , 8.0% in the placebo group, P =0.011).

In addition, it can only be administered by subcutaneous injection, not intravenous infusion, intramuscular infusion or intradermal injection. Patients must complete the injection under the supervision of professional medical staff.

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