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In malignant tumor bone metastasis, the OPG/RANKL/RANK axis plays a crucial role in the activation of osteoclasts. Denosumab can specifically bind to RANKL with high affinity and block the OPG/RANK/RANKL pathway, thereby inhibiting osteoclast activation and proliferation, reducing osteoclast activity, inhibiting bone resorption, reducing osteolysis, and blocking bone metastasis. It can reduce the incidence of SRE and delay the progression of bone pain.

On November 18, 2010, denosumab (denosumab) was approved to prevent bone-related events caused by cancer that has spread to the bone.

On June 13, 2013, denosumab (denosumab) was approved to treat adults and adolescents with giant cell tumor of bone (GCTB), a rare and usually noncancerous tumor. The price of denosumab (denosumab) produced by Amgen in the United States in Turkey is about 120mg/1500$.

In 2018, denosumab (denosumab) was included in the list of overseas new drugs in urgent clinical need (first batch) and entered the fast review channel of the National Medical Products Administration.

On May 27, 2019, Amgen announced in China that denosumab (denosumab) was approved by the National Medical Products Administration for the treatment of giant cell tumor of bone that is unresectable or whose surgical resection may cause severe functional disability, including adults and adolescent patients with skeletal maturity (defined as at least 1 mature long bone and body weight >45 kg).

Because the original drug is too expensive, patients have chosen denosumab (denosumab) sold by Amgen in Turkey, where the price is relatively affordable.

There are two ways for domestic patients to buy Turkish denosumab (denosumab): 1. Going abroad: If you are worried about buying counterfeit drugs, it is best to go directly to the original factory in Turkey to buy denosumab (denosumab). This can ensure the authenticity of the drug, so patients can go to Turkish hospitals to buy genuine products, and it is best to go to the top three hospitals in Türkiye. 2. Do not go abroad: Domestic professional overseas medical service institutions can help domestic patients purchase genuine and guaranteed Turkish (denosumab) without going abroad. If you have relevant medication needs, you can consult the medical companion travel service for details.

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