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It is mainly used to treat CMV infections such as retinitis, pneumonia, gastroenteritis, liver and central nervous system infections in patients with immunodeficiency. The main feature of ganciclovir is that its efficacy against CMV virus and hepatitis B virus infection is higher than that of currently used general drugs. In vitro experiments have shown that ganciclovir has strong activity against cytomegalovirus, HSV-1, HSV-2, varicella-zoster virus, and Epstein-Barr virus. Its inhibitory activity against cytomegalovirus and Epstein-Barr virus is 50 times stronger than acyclovir and 15 to 19 times stronger than foscarnet. According to Sadeo, ganciclovir can also effectively inhibit human herpes virus 6 (HHV-6) infection during allogeneic hematopoietic stem cell transplantation. It has also been reported that HBV mutant strains with DNA polymerase mutations are resistant to ACV and foscarnet (PFA), but are still sensitive to ganciclovir, indicating that there is another mode of action that is completely different from ACV.

Are valganciclovir hydrochloride tablets available in China?

Valganciclovir hydrochloride tablets were launched in China in 2006 and are suitable for the treatment of patients with acquired immunodeficiency syndrome (AIDS) combined with cytomegalovirus (CMV) retinitis and the prevention of CMV infection in high-risk solid organ transplant patients.

Valganciclovir hydrochloride is currently available in all major infectious disease hospitals and pharmacies in China. However, because it is an imported original drug, it is relatively expensive. The domestic valganciclovir hydrochloride specification is 450mg-60 tablets/box, and the price is approximately RMB 16,500.

If patients feel that the domestic price is unaffordable, they can also choose the original drug valganciclovir hydrochloride sold by Roche in India. The price is the lowest in the world and it is also the most purchased drug by domestic and foreign patients. India's Vancevir (valganciclovir hydrochloride tablets, valgansiklovir) 450mg*60 tablets/box is priced at about RMB 5,500. Due to the floating exchange rate, the price is not fixed. Please consult the medical companion for the specific price.