万赛维是什么药？

(valganciclovirhydrochloride), chemically named (S)-2-amino-3-methylbutyric acid 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester hydrochloride, is an oral anti-cytomegalovirus (CMV) infection drug developed by the Swiss company Roche. It was approved by the US FDA in May 2001. It is clinically used to treat acute retinitis caused by CMV infection in patients with acquired immunodeficiency syndrome (AIDS). In May 2003, its indications were expanded to prevent and treat secondary CMV infection in organ transplant recipients. This product is a prodrug of ganciclovir. After oral administration, it is rapidly hydrolyzed into ganciclovir by esterase in intestinal and liver cells, thereby exerting its medicinal effect. Its oral absorption bioavailability is 60%, which is 10 times that of 2, and its toxicity is greatly reduced.

At present, the main preparation and production methods of Vansevir are: 1. Use ganciclovir as raw material, then condense it with N-benzyloxycarbonyl-L-valine-N-acyl anhydride (or N-benzyloxycarbonyl-L--valine), and obtain ganciclovir monoester by controlling the reaction conditions, and then hydrogenate Reduction synthesis of valganciclovir hydrochloride; 2. Use ganciclovir as raw material, first protect one hydroxyl group with orthoester, and then condense it with N-benzyloxycarbonyl-L-valine and another hydroxyl group to obtain the diester ester, and then synthesize valganciclovir hydrochloride through hydrolysis reaction and hydrogenation reduction reaction. 3. Using purine compounds as raw materials, react with active electrophiles to obtain the monoester product of ganciclovir, and then undergo hydrogenation and deprotection to obtain valganciclovir hydrochloride.

Adverse reactions: (1) Gastrointestinal system: abdominal distension, cholangitis, indigestion, dysphagia, hiccups, esophagitis, fecal incontinence, flatulence, gastritis, gastrointestinal dysfunction, gastrointestinal bleeding, oral ulcers, pancreatitis, Tongue function disorder; (2) Systemic diseases: ascites, weakness, bacterial, fungal and viral infections, bleeding, fatigue, mucosal diseases, pain, photosensitivity, chills, sepsis; (3) Liver function: hepatitis, jaundice, etc.