万赛维治疗CMV视网膜炎的疗效如何呢？

CMV retinitis is a common syndrome that threatens the vision of AIDS patients and bone marrow and organ (liver, kidney, heart, etc.) transplant patients. Ganciclovir has good efficacy in treating cytomegalovirus infection, but its oral bioavailability is very low (6%~9%) and it can only be injected intravenously. CMV infection usually requires long-term maintenance treatment after induction therapy. Intravenous injection is used for long-term treatment, which is inconvenient and difficult for patients to accept. (Valganciclovir Hydrochloride Tablets) is a prodrug of ganciclovir. Oral administration can achieve the efficacy of injected ganciclovir and is suitable for long-term treatment of cytomegalovirus infection.

So what is the efficacy of Vansevir (valganciclovir hydrochloride tablets) in treating CMV retinitis?

Clinically, the antiviral effect of Valganciclovir Hydrochloride Tablets has been confirmed by treating AIDS patients with newly diagnosed retinitis (clinical study WV15376). After 4 weeks of treatment with valganciclovir hydrochloride tablets, the detection rate of CMV virus decreased from 46% (32/69) to 7% (4/55). 

Clinical studies of valganciclovir hydrochloride tablets in AIDS patients infected with CMV retinitis have shown that valganciclovir hydrochloride tablets and intravenous ganciclovir are equally effective in the induction treatment of CMV retinitis. In the study, patients with newly diagnosed CMV retinitis were randomly assigned to the valganciclovir hydrochloride tablet group or the intravenous ganciclovir group for induction therapy. The proportion of patients with progression of CMV retinitis at week 4 was the same in both groups. After induction therapy, both groups of patients in the study continued to receive maintenance therapy with valganciclovir hydrochloride tablets 900 mg per day. Among patients who received induction therapy with tablets or intravenous ganciclovir followed by maintenance therapy with Vancevir tablets, the mean (median) time from randomization to progression of CMV retinitis was: 226 (160) days and 219 (125) days.