总胆红素偏高患者怎么服用培米替尼？

How should patients with high total bilirubin take pemetinib?

Pemetinib is a kinase inhibitor drug that can block the proliferation of cancer cells and slow down the spread of cancer cells. It can be used to treat adult patients with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma and adult patients with relapsed or refractory myeloid/lymphoid neoplasms (MLN) associated with fibroblast growth factor receptor 1 (FGFR1) rearrangement.

Reduce recommended dosage in patients with severe hepatic impairment (total bilirubin > 3 × ULN with any AST). The recommended dose of pemetinib for patients with severe hepatic impairment (total bilirubin > 3 × ULN with any AST) is 9 mg, and the treatment regimen (intermittent or continuous) is indicated according to the indication.

No dose adjustment is recommended in patients with mild (total bilirubin > upper limit of normal [ULN] to 1.5 × ULN or AST > ULN) or moderate (total bilirubin > 1.5–3 × ULN with any AST) hepatic impairment.

When treating cholangiocarcinoma, the recommended dose of pemetinib is 13.5 mg, taken orally once daily for 14 days, followed by 7 days off, for a total cycle of 21 days. Continue treatment until disease progression or unacceptable toxicity.

The recommended dose of pemetinib for the treatment of FGFR1-rearranged myeloid/lymphoid neoplasms is 13.5 mg orally once daily. Continue treatment until disease progression or unacceptable response.

Missed Pemetinib Dose If you miss a dose by 4 hours or more, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.

It is not recommended for pregnant women or women planning pregnancy. Strict contraception is required while taking pemetinib. Pemetinib may harm the fetus. Breastfeeding women should not breastfeed while taking pemetinib and for 1 week after the last dose. It is recommended that patients take medication under the guidance of a doctor and receive symptomatic treatment. For more details on medication, please read the instructions.

Recommended related articles: