氨己烯酸片是什么药？治疗什么病？

What kind of medicine is vigabatrin tablets? What disease is treated? Vigabatrin tablets were approved by the US FDA in August 2009 and are suitable for monotherapy in children aged 1 month to 2 years old. The potential benefits of infantile spasms outweigh the potential risk of vision loss and can be used as an auxiliary (additional) treatment (CPS) for adult patients with refractory complex partial epilepsy. On January 16, 2019, the FDA approved the launch of a generic version of Vigabatrin. 

The main component of vigabatrin tablets is vigabatrin (vigabatrin). Its mechanism of action is to irreversibly inhibit GABA aminotransferase (GABA-T) and increase the concentration of GABA in the brain. In the past two years, more and more children with TSC have effectively controlled epilepsy by using vigabatrin tablets (Vigabatrin). Western countries even use vigabatrin tablets and Vigabatrin to prevent brain abnormalities in children with TSC who have not yet developed the disease. It can be seen that the effect is quite significant.

Experimental method: 10 children with TSC and IS who were treated with vigabatrin tablets from February 2013 to July 2015 were collected, their treatment conditions were retrospectively analyzed, and their clinical efficacy and adverse reactions were observed. Results The cumulative application time of vigabatrin tablets and Vigabatrin in this group ranged from 1 to 49 months, with a median time of 10 months. After diagnosis, 2 cases were first treated with vigabatrin tablets, and vigabatrin was added after other drug treatments were unsatisfactory. Among them, 8 cases of spasm disappeared or were close to disappearing, 1 case did not improve, and 1 case improved after adding adrenocorticotropic hormone. 6 cases took effect within 1 week, 1 case took effect on 15 days and 60 days respectively, and the average onset of effect was 5 days. The drug was well tolerated in 10 cases and the adverse reactions were mild.

The trial conclusion shows that vigabatrin tablets and Vigabatrin have good effects in the treatment of tuberous sclerosis and infantile spasms, with fast onset of action and good tolerability, and can be used as first-line treatment drugs.

Treatment with Vigabatrin may affect your ability to drive and use machinery. Generally, patients with uncontrolled epilepsy are not allowed to drive or operate potentially dangerous machinery. In view of reports of drowsiness during clinical use of vigabatrin tablets Vigabatrin, patients should be warned before initiating treatment with this drug. Vigabatrin tablets are oral medicines that can be taken once or twice a day, before or after meals. It is advisable to drink half a glass of water when taking this medicine. The use of vigabatrin tablets and vigabatrin should be done under the guidance of an epilepsy expert or a child neurologist. Reactions after taking the medication should be reported to the doctor promptly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.