sirolimus对肾移植有效吗？

Based on previous clinical experimental research results, sirolimus has a relatively obvious effect on kidney transplant patients, and patients can purchase and use it with confidence.

There have been many studies on the application of sirolimus-based immunosuppressive regimens in other solid organ transplants. A study published abroad in 2011 showed that recipients who switched to sirolimus 3 months after kidney transplantation had better renal function than recipients treated with CNI-based regimens 5 years after transplantation.

Domestic research has also shown through prospective randomized controlled studies that sirolimus conversion therapy in patients with stable renal function early after kidney transplantation can significantly improve renal function, and no increase in acute rejection and other adverse events was found during the 2-year follow-up period.

In a multicenter clinical study, 31 patients with chronic allograft nephropathy (suggesting chronic nephrotoxicity of calcineurin inhibitors, with or without nonspecific renal interstitial fibrosis or tubular atrophy) diagnosed by transplant kidney biopsy were treated with a treatment regimen that switched from calcineurin inhibitors to sirolimus, with an average follow-up of 21.6 months.

The results showed that 1 year after switching to sirolimus treatment, the patient's renal function was significantly improved [cGFR: (40.8±2.36) mL/min vs. (55.7±3.6) mL/min; P < 0.000]. No kidney transplant loss or patient death was observed during follow-up.

One year after switching to sirolimus treatment, procedural biopsies were performed and found that 8 (30%) patients improved, 11 (42%) had stable performance, and 7 (28%) had worsening in terms of renal interstitial fibrosis/tubular atrophy, glomerulosclerosis, and chronic vascular disease scores. Moreover, univariate analysis found that the patient's glomerular filtration rate ≥40.6 mL/min, serum creatinine ≤23.4 mg/L, and pathological tissue damage score ≤3 points at the time of conversion were predictive factors for the success of conversion therapy.