What is the mechanism of action of Vonoprazan?

Vonoprazan(Vonoprazan) is a potassium competitive acid blocker used to treat acid-related diseases and as an adjunct to the eradication of Helicobacter pylori. Vonoprazanis a potassium competitive acid blocker(PCAB)+, K+-ATP enzyme system competes with potassium. Through this mechanism, vonoprazan inhibits the secretory surface of gastric parietal cells and stimulates gastric acid secretion. Although both classes of drugs inhibit H+, K+-ATPase, the mechanism of action of PCABs is different from that of proton pump inhibitors (PPIs). PPIsform covalent disulfide bonds with the cysteine residues on H+, K+-ATPK+-ATP span>enzymes, causing enzyme inactivation, while PCBs interfere with the binding of potassium+ to H+, K+adenosine triphosphatase. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.