Is lenvatinib/lenvatinib (Lenvima) the same as the drug of the same name?

In the field of anti-cancer targeted drugs, many drugs will appear in different markets"similar drugs" or "generic drugs", Lenvatinib/Lenvatinib is no exception. Many patients will find that "lenvatinib", "lenvatinib", "Lenvima" or "Lenvatinib" have multiple names when searching, so they often wonder whether these drugs are exactly the same. In fact, these names are mostly derived from different brand naming systems, but the drug ingredients and mechanisms of action are the same in most cases.

The generic name of LenvatinibLenvatinib, and "Lenvatinib" is its Chinese translation; the trade name "Lenvima" is the original research brand launched by Japan Eisai Company. No matter how the name changes, its core active ingredient is Lenvatinib mesylate, which mainly blocks tumor angiogenesis and cell signaling by inhibiting various receptor tyrosine kinases such as VEGFR1-3, FGFR1-4, PDGFRα, RET and KIT. In other words, "Lenvatinib", "Lenvatinib" and "Lenvima" belong to the same drug in the pharmacological sense.

However, at the market level,"drugs with the same name" sometimes include versions produced by different manufacturers. For example, although generic drugs in some countries use the same generic name Lenvatinib, they are produced by local pharmaceutical companies, such as Beacon Company in Bangladesh and Incepta in Laos. These generic drugs strive to be consistent with the original drugs in terms of ingredient content and pharmacokinetics. However, due to slight differences in raw material sources, preparation processes and quality control standards, there may be slight differences in bioequivalence or dissolution rate.

From a clinical efficacy perspective, generic drugs have similar therapeutic effects to original drugs. However, in some strict regulatory systems (such asFDA or EMA), the safety and consistency of original drugs are more fully verified. Therefore, for patients with more complex conditions or patients who require long-term treatment, doctors usually use authoritatively certified versions.

Reference materials:https://www.lenvima.com/