Can Acotiamide cure indigestion?

Acotiamide cannot fundamentally "cure" functional dyspepsia (Functional Dyspepsia), but it can effectively control symptoms, improve gastric motility and improve quality of life. Functional dyspepsia is a functional disease of the gastrointestinal tract and is not caused by organic lesions. Its pathogenesis is complex and involves delayed gastric emptying, gastric adaptability disorders, abnormal vagus nerve regulation, and psychological factors. Therefore, the current goal of clinical treatment is to reduce symptoms through drug and lifestyle intervention rather than complete cure.

Acotiamide has significant efficacy in improving the core symptoms of FD - postprandial fullness, early satiety, and upper abdominal fullness. Its mechanism of action is to enhance gastric motility by inhibiting acetylcholinesterase, thereby helping food leave the stomach faster and reducing discomfort caused by gastric retention. At the same time, research has found that acotiamide can also improve the "adaptive expansion" function of the stomach, allowing the patient's stomach to relax better when eating and relieve early satiety. This mechanism of action is different from traditional gastric motility drugs (such as domperidone, mosapride), so it is often used in patients who have poor response to traditional treatments.

However, medication is only one part of management. The occurrence of functional dyspepsia is closely related to the pace of life, eating habits and psychological state. Patients are advised to have a regular schedule to avoid overwork and mental stress; eat small meals frequently and avoid overeating and late-night snacks; consume more vegetables and fruits rich in dietary fiber and reduce the intake of greasy, spicy and caffeinated foods; moderate exercise such as walking, yoga, etc. can help promote gastrointestinal motility. At the same time, maintaining a happy mood is equally important for gastric function recovery.

In general, acotiamide is not a "cure", but as a new functional dyspepsia treatment drug, it can provide patients with sustained symptom relief and significant improvement in quality of life. If combined with scientific lifestyle management, most patients can achieve long-term and stable symptom control.

Reference: https://www.rad-ar.or.jp/siori/english/search/result?n=33322