Reasons and treatment methods for no obvious reaction after taking DaliRasheng (Keweike) for 20 days

Daridorexant is a new type of dual oxindole receptor antagonist (DORA), which works by antagonizing OXR1< /span> and OXR2 receptors regulate the sleep-wake cycle, thereby improving falling asleep and maintaining sleep. Although some patients can feel improvement in the early stages of use, clinical data shows that most patients need to continue taking the medication for 1 to 4 weeks to observe significant sleep improvement. Therefore, if there is no obvious effect after taking it for 20 days, it may be due to individual slow onset of action or physiological differences.

The recommended dose of DaliRasen is 10mg to 25mg once for adults (the specific dose needs to be guided by a doctor), and should be taken orally 30 minutes before going to bed. If the patient does not strictly follow the doctor's instructions to take the medicine at a fixed time, does not follow adequate sleep environment conditions, or uses a low dose, it may affect the optimal efficacy of the medicine. In addition, the simultaneous use of other sedative-hypnotic drugs or stimulating substances such as caffeine and alcohol may also weaken the effect of DaliRasen.

There are individual differences in the onset of drug effects, which are related to age, liver and kidney function, comorbid diseases (such as depression, anxiety), and genetic metabolism differences. Some patients have rapid metabolism or complex sleep disorders (such as accompanied by periodic limb movements or breathing disorders), and it may be difficult for a single drug to significantly improve sleep in the short term. In this case, the drug needs to be combined with behavioral intervention (sleep hygiene improvement, cognitive behavioral therapy, etc.) to obtain a more obvious effect.

If there is still no obvious response after taking 20 days, you should first report to your doctor to evaluate whether the dose needs to be adjusted or the course of treatment needs to be extended, and other sleep-disturbing factors should be investigated. The doctor may recommend maintaining the current dose for 1 to 2 weeks, or adjusting the dose appropriately within a safe range. During this period, you should maintain a regular schedule, optimize your sleep environment, and avoid irritating substances. If it continues to be ineffective, you can consider combining other treatments or changing to suitable hypnotic drugs, and review them regularly to ensure the safety of the medication.

Reference materials:https://www.drugs.com/