Mitotane purchase price in China

Mitotane (Mitotane) is a special anti-tumor drug used to treat adrenocortical cancer (ACC; Adrenal Cancer). It is also one of the important long-term systemic treatment options in current international guidelines. This drug is a selective adrenocortical toxicity drug that affects the mitochondrial structure of adrenocortical cells and the steroidogenic pathway, causing the adrenal tissue to gradually shrink, thereby reducing excessive secretion of hormones and delaying tumor progression. Due to its unique mechanism of action, mitotane is used globally as adjuvant therapy after surgery, in inoperable locally advanced cases, and in patients with metastatic adrenocortical cancer. Overseas guidelines generally emphasize the importance of long-term maintenance of appropriate blood drug concentrations. Therefore, endocrine assessment and hormone replacement need to be combined during treatment, which is the most distinctive part of its application.

In terms of purchase price in China, the original drug of mitotane has been officially launched in the form of 500mg*100 tablets, but it has not yet been included in the national medical insurance catalog, so patients need to bear the cost of the drug. According to public information and quotations from some pharmacy channels, the domestic selling price of mitotane’s original drug is mostly more than 9,000 yuan per box. The price is affected by factors such as import channels and regional differences. Since it is not covered by medical insurance, the current financial burden on patients is relatively heavy, especially when long-term medication is required.

In overseas markets, in addition to original research products, there are also lower-priced imitation versions. The specifications of the generic version of mitotane produced in some areas, such as Laos, are the same as the original version, 500mg*100 tablets. The price is usually around more than one thousand yuan, but it will be affected by exchange rate fluctuations. It should be noted that such generic drugs may be different from original products in terms of quality standards, registration supervision, drug stability, etc. Therefore, patients should be cautious when choosing and try to consult professional doctors through formal channels.

References: https://go.drugbank.com/drugs/DB00648