Detailed explanation of the side effects and treatment methods of Lemborexant

Lemborexant is a new generation of "dual orexin receptor antagonist" (DORA) sleeping pills. Its safety and tolerability are considered to be better than traditional sleep aids, but certain adverse reactions may still occur. Many patients may experience brief fluctuations in their sleep experience and body response in the first few days after starting to use it. This is a process in which the drug gradually "synchronizes" with the individual's sleep rhythm. The most common side effects include mild dizziness, prolonged drowsiness, vivid dreams, slight loss of balance, etc. Most of these reactions are transient and tend to resolve naturally after continuous use.

Some patients will experience slight fatigue in the morning, which is mainly related to the mechanism of the drug inhibiting wakefulness signals. It is usually recommended to move the medication time forward to allow the medication to be metabolized during a more stable nighttime cycle, which can reduce the effects the next day. Vivid dreams or increased awakenings at night are mostly temporary reactions caused by adjustments to the REM phase. Don’t worry too much, it can be alleviated by maintaining a regular schedule.

For a small number of patients who experience obvious dizziness or changes in their sense of balance, which are usually related to individual metabolic capacity, drug concentration, or comorbid diseases, these patients should initially reduce their movements of getting up quickly at night and observe whether the symptoms improve within a few days. If significant discomfort occurs, discuss with your doctor to adjust the dose or evaluate for interactions with concurrent medications, such as antidepressants, anti-anxiety medications, or certain antifungal medications that affect metabolic pathways.

If rare worsening of insomnia, abnormal behavior or emotional reactions occur, the medication needs to be stopped as soon as possible and evaluated by a professional. But overall, the side effects of leborexan are mostly mild to moderate, and the incidence rate is lower than that of traditional benzodiazepines and Z drugs. It does not affect muscle tone and does not cause strong daytime sleepiness, making it more suitable for long-term sleep disorder management.

Reference materials:https://medlineplus.gov/druginfo/meds/a620039.html