Correct storage method of somituximab (Mirvetuximab)

Mirvetuximab (Mirvetuximab), as an innovative antibody drug conjugate (ADC), plays a precise targeting role in the treatment of epithelial ovarian cancer and related tumors. In order to ensure its efficacy and safety, correct storage methods are crucial. Somituximab is usually provided under the brand ELAHERE, and each bottle of solution must be stored in strict accordance with the prescribed conditions. Medications should be placed upright in a refrigerator at 2℃ to 8℃ (36℉ to 46℉) to avoid temperature fluctuations and exposure to light, so it is recommended to place the medicine bottles in the original carton to avoid light. Do not freeze or shake the medicinal solution during storage to prevent protein structure damage or drug component failure.

In addition, somituximab is a hazardous drug and its handling and disposal must follow professional guidelines and hospital standard operating procedures. Unused medicinal solutions or discarded containers should not be discarded at will and should be disposed of in accordance with hazardous drug management practices to avoid environmental pollution or potential risks to medical staff. Patients and medical staff should read the drug instructions carefully before use to ensure that storage and operation meet the requirements.

The stability and efficacy of drugs depend largely on storage conditions. Any excessive temperature or light exposure may lead to protein degradation, thereby affecting the targeting and anti-tumor activity of ADC in the body. Overseas drug management guidelines all emphasize that somituximab should be maintained at an appropriate temperature before use, and vigorous shaking or vigorous stirring should be avoided during preparation and infusion.

Therefore, in order to ensure the efficacy and safety of somituximab in clinical use, strict compliance with storage conditions, avoidance of freezing and shaking, and proper disposal of drug waste are key aspects that every medical staff and patient must pay attention to. Through standardized storage and operation, it can be ensured that ADC can exert the best anti-tumor effect during the infusion process, improve the therapeutic effect and reduce potential risks.

Reference materials:https://www.elahere.com/