Contraindications of tenofovir alafenamide fumarate tablets (Vemlidy)

Tenofovir alafenamide fumarate tablets (Vemlidy/Vemlidy) is an important oral drug in the treatment of hepatitis B . Although the overall safety is relatively high, patients still need to fully understand the contraindications and precautions for medication to ensure the safety and effectiveness of long-term medication. As a highly selective new tenofovir prodrug, Vemlidy’s metabolism, excretion pathways and interactions with other drugs make it unsuitable for casual use in certain groups of people.

First of all,One of the core taboos of Vemlidy is allergies to drug ingredients. If the patient has a known history of allergy to tenofovir or excipients, use should be avoided to prevent severe allergic reactions. Patients who have experienced rash, respiratory reactions, or systemic discomfort from previous use of other antiviral drugs should be evaluated by a physician for risk of cross-sensitivity before starting treatment with Vemlidy.

Secondly, patients with severe renal insufficiency or undergoing dialysis should use it with caution or be prohibited from using it. Although Vemlidy is safer with respect to the kidneys, its excretion is still partially dependent on kidney function, so in patients with significantly reduced kidney function, the drug may accumulate, leading to an increased risk of unnecessary side effects.

In addition,Vemlidy is not suitable for patients who are co-infected with HIV but not receiving combination antiretroviral therapy. Since this drug inhibits some aspects of HIV replication, it may cause the risk of drug resistance if used alone. Therefore, once HIV infection occurs, it should be managed in conjunction with other antiviral drugs and used as directed by your doctor.

For pregnant and lactating women, although existing data show that the safety is relatively controllable, individualized evaluation is still needed. Due to the large physiological changes during pregnancy, drug metabolism may be different, so a professional doctor should be allowed to judge whether it is appropriate to continue using it based on the specific situation. .

Finally, patients should avoid stopping the medication without authorization while usingVemlidy. Sudden discontinuation of medication may lead to acute rebound of hepatitis B and worsening of liver function. There are many related cases reported. Therefore, if any discomfort occurs during the treatment, the plan should be adjusted under guidance instead of interrupting on your own.

Reference materials:https://www.vemlidyhcp.com/