Can avatrombopag (Su Kexin) be chewed and taken and what precautions should be taken

Avatrombopag (Avatrombopag ) is an oral thrombopoietin receptor agonist, mainly used for the treatment of patients with chronic liver disease-related thrombocytopenia and other thrombocytopenia. This medication is usually taken by mouth as a whole tablet to ensure sustained release, stable absorption, and optimal efficacy. Both official instructions and clinical practice emphasize that avatrombopag is not recommended to be chewed or crushed for administration, as this may destroy the formulation properties of the drug and lead to abnormal absorption rates, thereby affecting blood concentration and efficacy.

If the patient has difficulty swallowing or needs to adjust the administration method under special circumstances, this should be done under the guidance of a doctor. In some cases, doctors may provide a dosage regimen that can be dissolved in a small amount of water or combined with food, but the tablet must be taken whole or used according to the instructions to avoid reduced efficacy or increased adverse reactions. Chewing and taking without professional guidance may cause the drug to be released too quickly, causing fluctuations in platelet levels or potential side effects, such as headaches, fatigue, or an increased risk of bleeding.

When taking medication, you also need to pay attention to interactions with food and medications. Avatrombopag should be taken before or with a meal to optimize absorption, and avoid taking it with supplements rich in minerals such as calcium, iron, and magnesium, as these elements may interfere with drug absorption. In addition, patients should regularly monitor their platelet count during medication so that the dose can be adjusted in a timely manner to ensure that the platelet level is within a safe range.

Finally, patients should keep good medication records when using avatrombopag and truthfully report any abnormal symptoms, such as bleeding, bruising, or dizziness, to their doctor. Following professional medical advice and avoiding changing the administration method on your own are important prerequisites for ensuring the efficacy and safety of avatrombopag. Scientific and standardized taking methods can maximize the effects of drugs while reducing the risk of adverse reactions.

Reference materials:https://www.drugs.com/