Is Tilorisen (Harcos) an antihypertensive drug? Analysis of pharmacological mechanisms and central nervous system effects

Pitolisant (Pitolisant) is not an antihypertensive drug. Its main indication is central nervous system diseases, especially the treatment of narcolepsy (narcolepsy). It is a histamine H3 receptor antagonist / inverse agonist, which works by regulating the histamine system in the brain rather than directly regulating blood pressure or the cardiovascular system. Therefore, the clinical use of tilolixen is not directly related to antihypertensive treatment, although minor changes in blood pressure may be observed in individual cases.

In terms of pharmacological mechanism, tilolixen inhibits the negative feedback regulation of histamine itself by antagonizing or inversely stimulating the H3 receptors in the central nervous system, thereby increasing the release and activity of histamine in the brain. As an important neurotransmitter, histamine is involved in the regulation of arousal, attention, learning and memory. By enhancing histaminergic nerve signals, tilorisen can improve patients' daytime sleepiness symptoms, improve arousal level and cognitive function, and this effect is independent of the blood pressure control mechanism.

In terms of effects on the central nervous system, Pitolisant not only enhances histaminergic nerve activity, but also indirectly affects neurotransmitter systems such as norepinephrine, dopamine and acetylcholine. Modulation of these neurotransmitters helps increase alertness, concentration, and information processing speed while improving cognitive and behavioral functions. Therefore, the effect of tilorisen in the central nervous system is mainly reflected in the regulation of arousal and cognitive functions rather than direct intervention in the cardiovascular system.

Clinical application suggests that Pitolisant can be used as an effective treatment option for narcolepsy and related neuropathic sleepiness conditions. Its safety is generally good, but central-related side effects such as mild headache, insomnia, nausea or anxiety may occur. During use, it is necessary to follow the guidance of a doctor and pay attention to changes in cognitive function, sleep patterns and neurological symptoms. In general, tilorisen is a central nervous system modulating drug rather than an antihypertensive drug. Its main effect is to improve arousal state and central cognitive function rather than directly affecting blood pressure levels.

Reference materials:https://www.drugs.com/