Are ruxolitinib tablets/ruxolitinib generic drugs reliable?

Ruxolitinib is a targeted drug widely used to treat myelofibrosis (MF), polycythemia vera, and graft-versus-host disease (GVHD). As the original drug market matures, more and more generic drugs have entered the market, providing more economical options. In recent years, some generic drugs of ruxolitinib have also been launched overseas, including generic drugs produced by Lucius Pharmaceutical Factory in Laos. These generic drugs contain the same ingredients as the original drugs and should theoretically have similar efficacy and safety. However, there is still a question of concern as to whether generic drugs are completely reliable.

First, generic drugs are usually held to the same quality standards as the brand-name drugs. According to international drug standards, generic drugs need to pass preclinical bioequivalence tests to prove that their absorption, distribution, metabolism and excretion processes in the body are similar to those of the original drugs. This means that generic drugs should have the same active ingredients and similar clinical effects as the brand-name drugs. Therefore, under strict quality control, generic ruxolitinib drugs are reliable in most cases.

However, there may be differences in the production process and raw material sources of generic drugs, especially in the stability of the drug, dosage form and selection of excipients. Although the basic ingredients of generic drugs are the same as those of the brand-name drugs, due to differences in production processes, some patients may experience side effects or effects that are slightly different from those of the brand-name drugs.

In terms of price, the advantages of generic drugs are obvious, especially in some economically developing countries, where the price of generic drugs is often much lower than that of original drugs. Take the generic ruxolitinib produced by Laos Lucius Pharmaceutical Factory in 5mg*60 tablets as an example. Its price may only be more than 700 yuan, and the price difference is very obvious. However, when choosing a generic drug, patients should ensure that the drug comes from a certified manufacturer and meets the regulatory standards of the local drug administration department.

Reference materials:https://www.jakavi.com/