How effective is Tilpotide/Tilsipatide (Mufengda) in weight loss? Actual clinical performance analysis

Tirzepatide (Tirzepatide) is a novel dual agonist that acts on GLP-1 and GIP receptors and has shown significant weight loss effects in addition to diabetes management. Clinical studies have shown that tilpotide can reduce total energy intake and help patients achieve sustained weight loss by delaying gastric emptying, increasing satiety and regulating appetite. This mechanism makes it more effective than traditional weight loss drugs in obese and overweight patients.

In actual clinical performance, Tirzepatide has a significant weight loss effect. Taking the 2022 series of STEP and SURPASS studies as an example, after 26 to 72 weeks of treatment, The average weight loss of patients treated with medium and high doses of Tirzepatide can reach 15% to 20%, and some patients even exceed 20%, which is much higher than the average level of traditional oral weight loss drugs. This weight loss is usually accompanied by a reduction in waist circumference and an improvement in body fat ratio. It also has a certain improvement effect on obesity-related metabolic abnormalities, such as glycemic control, blood pressure and blood lipid level optimization.

However,Tirzepatide is also accompanied by certain adverse reactions during the weight loss process. The most common are gastrointestinal symptoms, such as nausea, vomiting, diarrhea and constipation, which mostly occur at the beginning of treatment and decrease with gradual dose adjustment. In addition, some patients may be at risk for hypoglycemia, especially diabetic patients taking concomitant insulin or sulfonylurea drugs. Therefore, clinical use requires individualized dose adjustment and monitoring of blood sugar and overall tolerance under the guidance of a professional physician.

In general, tilpotide has excellent weight loss effects. It can not only significantly reduce body weight, but also improve obesity-related metabolic indicators. It is suitable for patients who need long-term weight control or have diabetes. Its weight loss effect is sustainable, but it needs to be used under the guidance of a doctor, and attention should be paid to gastrointestinal side effects and the risk of hypoglycemia. Combining healthy diet and lifestyle intervention, Tirzepatide can provide obese patients with a safe, efficient and scientific weight loss treatment option.

Reference materials:https://go.drugbank.com/