Are there any complications from taking tepotinib?

Some complications and adverse reactions may occur during the use of Tepotinib (tepotinib). It is mainly used to treat adult patients with metastatic non-small cell lung cancer with mesenchymal-epithelial transition (MET) exon 14 skipping changes. Due to individual differences and different patient conditions, the specific complications will vary.

Affecting more than 1 in 5 patients, the most common side effects of tepotinib are edema (a buildup of fluid), nausea (feeling sick), low levels of albumin in the blood, diarrhea, and elevated levels of creatinine in the blood (a sign of kidney problems). Possibly affecting more than 1 in 100 people, the most common serious side effects of tepotinib are peripheral edema (especially swelling of the ankles and feet), anasthenia (a buildup of fluid throughout the body), and interstitial lung disease (a condition that causes scarring of the lungs). The most common grade 3-4 laboratory abnormalities were lymphopenia, decreased albumin, decreased sodium, increased gamma-glutamyl transferase, increased amylase, increased ALT, increased lipase, increased AST, and decreased hemoglobin.

The original drug Tepotinib is a new type of drug that has not yet been marketed in China, so it has not been included in the medical insurance. Domestic patients cannot yet purchase this drug in pharmacies or hospitals. The price of Tepotinib's original drug specification 225mg*30 tablets per box is around RMB 80,000 per box (the price may fluctuate due to exchange rate effects). It has been on the market for a short time and is expensive. There are also generic Tepotinib drugs produced in other countries. The price of a box of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode’s medical consultant.