Does tepotinib affect pregnant women?

There are no available data on the use of tepotinib in pregnant women.tepotinib. Based on the area under the curve (AUC) at the 450 mg daily clinical dose, oral administration of tepotinib to pregnant rabbits during the period of organogenesis resulted in maternal exposure to malformations (teratogenicity) and abnormalities that were lower than human exposure, and patients should be informed of the potential risk to the fetus during use.

In embryonic-fetal development studies, pregnant rabbits received daily oral doses of 0.5, 5, 25, 50, 150, or 450 mg/kg tepotinib hydrochloride hydrate during organogenesis. Severe maternal toxicity occurred at the 450 mg/kg dose (approximately 0.75 times the human exposure at the 450 mg clinical dose). , recommend that women not breastfeed during treatment with tepotinib and for one week after the last dose, and that women of reproductive potential use effective contraception during treatment with tepotinib and for one week after the last dose.

The original drug Tepotinib is a new type of drug that has not yet been marketed in China, so it has not been included in the medical insurance. Domestic patients cannot yet purchase this drug in pharmacies or hospitals. The price of Tepotinib's original drug specification 225mg*30 tablets per box is around RMB 80,000 per box (the price may fluctuate due to exchange rate effects). It has been on the market for a short time and is expensive. There are also generic Tepotinib drugs produced in other countries. The price of a box of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode’s medical consultant.