What is the target of Brigatinib?

Brigatinib/Brigatinib (Brigatinib)’s main target is ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1).

ALK is a tyrosine kinase and belongs to the tyrosine kinase family. Under normal circumstances, ALK is involved in embryonic development and normal function of the nervous system. However, ALK gene fusion events or mutations can lead to abnormal activation of ALK in tumor cells, thereby promoting tumor growth and metastasis. Brigatinib/Brigatinib blocks the abnormal activation of the ALK signaling pathway by inhibiting the kinase activity of ALK, thereby inhibiting the proliferation and survival of tumor cells.

ROS1 is another tyrosine kinase that belongs to the same family. Fusion events or mutations in the ROS1 gene can also lead to abnormal activation of ROS1 and participate in the development of tumors. Brigatinib/Brigatinib not only has an inhibitory effect on ALK, but also shows high anti-tumor activity against ROS1. Therefore, Brigatinib/Brigatinib has important clinical significance in the treatment of ALK fusion-positive and ROS1-positive non-small cell lung cancer patients.

Brigatinib/Brigatinibby cooperating with ALK and ROS1Bind and inhibit their kinase activity, thus blocking the abnormal activation of downstream signaling pathways. This inhibitory effect can reduce the proliferation, survival and metastasis of tumor cells, thereby inhibiting tumor development.

Brigatinib/Brigatinib has been launched in China and has been included in medical insurance. Since it has just been approved for marketing, patients may not be able to buy it in domestic pharmacies. If you need to purchase it in China, please consult the local pharmacy. However, the price is quite high, more than 10,000 yuan. Foreign Brigatinib/Brigatinib are mainly generic drugs, mainly Bangladeshi and Laos generic drugs. The price of the international version of the Bangladeshi generic drug Yaopin is about 2000yuan, the specification is 90mg*30 tablets; the price of the Laos version of the generic drug is about 600, and the specification is smaller. And the ingredients of domestic original drugs and foreign generic drugs are basically the same.