Sorafenib usage and dosage

Sorafenib (Sorafenib) is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. In the United States, it is also indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid cancer that is refractory to radioactive iodine therapy. The recommended dose of sorafenib is 400 mg twice daily without food (at least 1 hour before or 2 hours after meals) until the patient no longer benefits from treatment or until unacceptable toxicity occurs.

For the treatment of hepatocellular carcinoma and renal cell carcinoma, the first dose of sorafenib is reduced to 400 mg orally once daily and the second dose is reduced to 200 mg orally once daily (or 400 mg every other day). For differentiated thyroid cancer, the first dose of sorafenib is reduced to 400 mg orally in the morning and 200 mg orally in the evening, about 12 hours apart (or 200 mg orally in the morning and 400 mg orally in the evening, about 12 hours apart), the second dose is reduced to 200 mg twice daily, and the third dose is reduced to 200 mg twice daily. If the patient does not recover after 30 days of interruption, treatment is discontinued unless the patient achieves clinical benefit. If the patient requires more than 2 dose reductions, it is recommended to permanently discontinue treatment.

SorafenibThe original drug has been launched in China and has entered the scope of medical insurance. Different regions have different reimbursement ratios, and the price after reimbursement may vary. SpecificationsThe price of 0.2g*60 tablets may be around RMB 1,200. The original drug of sorafenib has also been launched overseas, and there are also sorafenib generic drugs produced in other countries. The specifications produced by Bangladesh Pharmaceutical FactoryThe price of 0.2g*60 tablets is around 450 yuan (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of the original drug are basically the same as those of the generic drugs. For specific prices and drug details, please consult the medical consultant of Yaode.