Sorafenib resistance management

Sorafenib (Sorafenib) is a multi-kinase inhibitor that can promote apoptosis, alleviate angiogenesis and inhibit tumor cell proliferation. In advanced hepatocellular carcinoma (HCC), sorafenib is currently an effective first-line treatment. Unfortunately, resistance to sorafenib is increasingly common. Recent studies have shown that epigenetics, transport processes, regulated cell death, and the tumor microenvironment are associated with the development of sorafenib resistance in HCC and subsequent HCC progression.

Hepatocellular carcinoma(HCC) is the second leading cause of cancer-related death worldwide and usually occurs in patients with chronic liver inflammation associated with viral infection, alcohol overuse, or metabolic syndrome. Protein tyrosine kinase 2 (PTK2) was found to activate CSC properties and drive tumorigenicity by promoting nuclear accumulation of β-catenin in HCC cells, leading to sorafenib resistance. Sorafenib undergoes oxidative metabolism in the liver via CYP3A4 and glucuronidation in the liver and kidney via UGT1A9. At steady state, sorafenib accounts for 70-85% of circulating analytes in plasma. However, everyone’s physique is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

The original drug of sorafenib has been launched in China and has entered the scope of medical insurance. Different regions have different reimbursement ratios, and the price after reimbursement may vary. SpecificationsThe price of 0.2g*60 tablets may be around 1,200 yuan. The original drug of sorafenib has also been launched overseas, and there are also generic drugs of sorafenib produced in other countries. The price of 0.2g*60 tablets produced by a Bangladesh pharmaceutical factory is around RMB 450 (the price may fluctuate due to the exchange rate). The ingredients of the original drug are basically the same as those of the generic drugs. For specific prices and drug details, please consult the medical consultant of Yaode.