What is sunitinib?

Sunitinib (Sunitinib)is suitable for adult patients with gastrointestinal stromal tumors (GIST) who have progressed (or are intolerant) on imatinib mesylate treatment, adults Treatment of advanced renal cell carcinoma, adjuvant treatment of adult patients with high-risk recurrent renal cell carcinoma after nephrectomy, Treatment of progressive well-differentiated pancreatic neuroendocrine tumors (pNET) in adults with unresectable locally advanced or metastatic disease.

Sunitinib is a small molecule that inhibits multipleRTKs, some of which are associated with tumor growth, pathological angiogenesis, and cancer metastasis progression. Evaluate the inhibitory activity of sunitinib on multiple kinases(>80 kinases) through and identify them as platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 Inhibitors of (FLT3), colony-stimulating factor receptor type 1 (CSF-1R), and glial cell line-derived neurotrophic factor receptor (RET). Inhibition of the activity of these RTKs by sunitinib has been demonstrated in biochemical and cellular analyses, and inhibition of function has been confirmed in cell proliferation assays. In biochemical and cellular analyses, the major metabolites showed similar potency to sunitinib.

The original sunitinib drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of 12.5mg*28 tablets is around RMB 3,500. The original sunitinib drug has also been launched overseas. The price of 12.5mg*7 tablets is around RMB 1,500 (the price may fluctuate due to the exchange rate). There are also generic drugs produced in other countries. The price of 12.5mg*28 tablets produced by an Indian pharmaceutical factory is around RMB 750 (the price may fluctuate due to the exchange rate). The generic drugs produced abroad are basically the same as the original drugs at home and abroad. There may be differences in the prices of different specifications of drugs.