How much does a box of Cabozantinib cost?

Cabozantinib (Cabozantinib) is a multi-target tyrosine kinase inhibitor that acts on multiple receptor kinases and receptor tyrosine kinases, thereby interfering with the transmission of multiple cell signaling pathways.

Cabozantinib is not currently on the market in China and is therefore not included in medical insurance because it requires approval from the National Medical Products Administration. Therefore, patients cannot purchase it domestically and need to purchase it through overseas channels. There are original and generic cabozantinib drugs abroad. The original drugs are mainly Japanese original drugs, Turkish original drugs and European original drugs. The price is relatively high, ranging from 35,000 to 46,000 yuan. Foreign generic drugs are mainly Lao generic drugs and Bangladeshi generic drugs, with prices ranging from 1,300 to 2,700 yuan. The price is much cheaper than original drugs and is more suitable for the needs of patients in ordinary families. The ingredients of original drugs and generic drugs are basically the same.

Cabotinib interferes with the signaling of growth and proliferation of various tumor cells by inhibiting the activity of receptor kinases. Among them, cabozantinib inhibits vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3) on the cell surface, hepatocyte growth Factor receptors (HGFR or c-Met), tumor-derived growth factor receptors (RET) and other receptor kinases. These receptors play critical roles in tumor growth, angiogenesis, metastasis, and progression.

Cabotinib inhibits the activity of VEGFR and reduces the angiogenesis induced by vascular endothelial growth factor (VEGF), thus inhibiting the blood supply of tumors. Angiogenesis is a process necessary for tumor growth and metastasis, and inhibition by cabozantinib helps slow tumor growth and progression.