Can Cabozantinib be purchased in Hong Kong?

Cabozantinib (Cabozantinib) is a multi-target tyrosine kinase inhibitor, and its therapeutic principle is based on the intervention of multiple signaling pathways. It acts on a variety of receptor kinases and receptor tyrosine kinases, thereby affecting key biological processes such as tumor cell growth, proliferation, angiogenesis, and metastasis. The following are the main principles of cabozantinib treatment:

Cabotinib inhibits multiple cell surface receptor kinases, including vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3). VEGF is the main signaling molecule that promotes angiogenesis. It promotes new blood vessel formation by binding to VEGFR on endothelial cells. Tumor cells require a large blood supply to support their growth and metastasis, so inhibiting angiogenesis can slow tumor growth.

Cabozantinib inhibits multiple receptor kinases, including hepatocyte growth factor receptor (HGFR or c-Met) and tumor-derived growth factor receptor (RET). These receptor kinases play key roles in tumor cell proliferation and growth. Inhibiting these receptor kinases can interfere with the growth signaling pathways of tumor cells and prevent cell proliferation and growth.

Currently, the original drug cabozantinib is not available in Hong Kong. Cabozantinib is not currently on the market in China and is therefore not included in medical insurance because it requires approval from the National Medical Products Administration. Therefore, patients cannot purchase it domestically and need to purchase it through overseas channels. There are original and generic cabozantinib drugs abroad. The original drugs are mainly Japanese original drugs, Turkish original drugs and European original drugs. The price is relatively high, ranging from 35,000 to 46,000 yuan. Foreign generic drugs are mainly Lao generic drugs and Bangladeshi generic drugs, with prices ranging from 1,300 to 2,700 yuan. The price is much cheaper than original drugs and is more suitable for the needs of patients in ordinary families. The ingredients of original drugs and generic drugs are basically the same.